Sodium Hydroxide → HCID 21463488、化合物

HRID 1940593ノート

反応式

HRID 1940593 の反応式
[N+:1]([O-:4])([O-])=[O:2].[K+].[NH2:6][C:7]1[C:15]2[O:14][CH2:13][CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:6][C:7]1[C:15]2[O:14][CH2:13][CH2:12][C:11]=2[CH:10]=[C:9]([N+:1]([O-:4])=[O:2])[CH:8]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 128059502,3-Dihydro-1-benzofuran-7-amine

生成物 1

HCID 21463488HCID 21463488、化合物収率 76%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

Potassium nitrate (8.6 g) was added portionwise over 1/2 h to a solution of 7-amino-2,3-dihydrobenzofuran (D3) (10 g) in concentrated sulphuric acid (75 ml) at 5°-10° C. The resulting solution was stirred for a further 2 h, then added to ice, basified with 40% NaOH, and extracted into ethyl acetate. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (10.1 g, 76%) as a red/brown foam.

後処理

  1. additionadded to ice
  2. extractionextracted into ethyl acetate
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-564bc4fed1db4bd58ced1f5f67e2190f
出典データセット
uspto-grants-1997_12
特許番号
US05700818

反応ノート

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