Pyridine → N-chloroacetyl-N-phenylglycine methyl ester

HRID 1940618

反応式

HRID 1940618 の反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1C=CC=CC=1.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH2:4][N:5]([C:21](=[O:22])[CH2:20][Cl:19])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 571509Methyl 2-(phenylamino)acetate

生成物 1

HCID 21463537N-chloroacetyl-N-phenylglycine methyl ester収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To methylene chloride (20 ml) was added N-phenylglycine methyl ester (2.02 g, 10 mmol) and pyridine (1.58 g, 20 mmol) and the mixture was stirred. To the mixture was added dropwise a solution of chloroacetyl chloride (1.13 g, 10 mmol) in methylene chloride (3 ml) at room temperature and the resulting mixture was stirred for 15 hours, washed with water, dried and evaporated. The resultant residue was crystallized from isopropyl ether to give N-chloroacetyl-N-phenylglycine methyl ester (1.67 g, 70%) as a colorless powder.

後処理

  1. stirringthe resulting mixture was stirred for 15 hours
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe resultant residue was crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-fa0f3908ea2d449ca8c20449227196e8
出典データセット
uspto-grants-1997_12
特許番号
US05700819

関連ノート

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