Thionyl Chloride → 2-(4-Methylphenyl)propionyl chloride

HRID 1941127

反応式

HRID 1941127 の反応式
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:16])[C:13](O)=[O:14])=[CH:8][CH:7]=1>>[CH3:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:16])[C:13]([Cl:3])=[O:14])=[CH:8][CH:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 1508662-(4-Tolyl)propanoic acid

生成物 1

HCID 149460792-(4-Methylphenyl)propionyl chloride収率 100.1%

反応条件

温度
60 °C

実験手順

160.65 g (1.35 mol) of thionyl chloride are placed in a 1 liter three-necked flask fitted with a mechanical stirrer and a condenser. 164.2 g (0.9 mol) of p-methylphenylpropionic acid are added little by little thereto at room temperature. After 4 hours, the reaction is terminated by heating at 60° C. for 1 hour. Excess SOCl2 is removed by distillation/n vacuo. In that manner 164.5 g of p-methylphenylpropionic acid chloride are obtained.

後処理

  1. customfitted with a mechanical stirrer and a condenser
  2. customthe reaction is terminated
  3. customExcess SOCl2 is removed by distillation/n vacuo

出典と根拠

ORDレコード
ord-980b86e2f0634cf3904e06b1c9e828f0
出典データセット
uspto-grants-1997_12
特許番号
US05703074

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