N-Iodosuccinimide → (5-Iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-propyl-amine

HRID 1942316ノート

反応式

HRID 1942316 の反応式
[S:1]1[C:5]([NH:6][CH2:7][CH2:8][CH3:9])=[N:4][N:3]2[CH:10]=[CH:11][N:12]=[C:2]12.[I:13]N1C(=O)CCC1=O>C(#N)C>[I:13][C:10]1[N:3]2[C:2]([S:1][C:5]([NH:6][CH2:7][CH2:8][CH3:9])=[N:4]2)=[N:12][CH:11]=1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 58285612Imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine

生成物 1

HCID 58285729(5-Iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-propyl-amine収率 36.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

663 mg of imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine were dissolved in 20 ml of acetonitrile. 822 mg of N-iodosuccinimide were added to the solution. The reaction mixture was stirred for 4 h at room temperature. For work-up, the mixture was cooled on ice and filtrated. 410 mg of the desired product were obtained.

後処理

  1. temperatureFor work-up, the mixture was cooled on ice
  2. filtrationfiltrated

出典と根拠

ORDレコード
ord-4683d2492c044513aec3142526f604e8
出典データセット
uspto-grants-2013_03
特許番号
US08389554B2

反応ノート

読み込み中…