Isopropanol → HCID 58404446、化合物

HRID 1942583ノート

反応式

HRID 1942583 の反応式
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][CH:15]([OH:17])[CH3:16].[H-].[Na+]>O1CCCC1>[CH3:14][CH:15]([O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])[CH3:16]

参加物

5

反応物 3

HCID 3776IsopropanolHCID 24758Sodium hydrideHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

生成物 1

HCID 58404446HCID 58404446、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-10 °C

実験手順

To a solution of 4-fluoro-3-(trifluoromethyl)benzonitrile (10 g), i-PrOH (8.15 mL) in tetrahydrofuran (THF) (90 mL) stirred under nitrogen at −10° C. was added solid NaH (3.46 g) portionwise during 30 min. The reaction mixture was stirred at −10° C. for 6 h. The reaction mixture was quenched with water, partitioned between ether (100 mL) and water (50 mL). The organic phase was dried over magnesium sulphate and evaporated in vacuo to give the crude product 4-[(1-methylethyl)oxy]-3-(trifluoromethyl)benzonitrile (D10) (15 g).

後処理

  1. customThe reaction mixture was quenched with water
  2. custompartitioned between ether (100 mL) and water (50 mL)
  3. dry with materialThe organic phase was dried over magnesium sulphate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-012129b40fcc43a78051dac56f5f4c69
出典データセット
uspto-grants-2013_03
特許番号
US08389508B2

反応ノート

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