Pyridine → n-Pentyltriflate
反応式
N1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)CCCC.[S:13]([O:20]S(C(F)(F)F)(=O)=O)([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14]>>[CH2:2]([O:20][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])[CH2:3][CH2:4][CH2:5][CH3:6]参加物
4
実験手順
To a nitrogen flushed round bottom flask equipped with a stir bar was added pyridine (0.81 mL, 10.0 mmol) and n-pentanol (1.09 mL, 10.0 mmol). The reaction was cooled in an ice bath and triflic anhydride (1.69 mL, 10.0 mmol) was added dropwise. The ice bath was allowed to melt over two hours at which time the entire reaction mixture was filtered over a column of silica gel eluting with dichloromethane. The filtrate was carefully evaporated in vacuo then carried on without further purification(1.11 g, 5.04 mmol).
後処理
- customTo a nitrogen flushed round bottom flask equipped with a stir bar
- temperatureThe reaction was cooled in an ice bath
- customthe entire reaction mixture
- filtrationwas filtered over a column of silica gel eluting with dichloromethane
- customThe filtrate was carefully evaporated in vacuo
- customthen carried on without further purification(1.11 g, 5.04 mmol)
出典と根拠
- ORDレコード
- ord-905ce1a5152a4b5a9c957a0b8bbd92f8
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08394828B2
反応ノート
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