Hydrochloric Acid → HCID 89077752、化合物

HRID 1946212ノート

反応式

HRID 1946212 の反応式
[CH3:1][C:2]1([CH3:28])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([O-:13])=O)[CH:9]=2)[N+:4]2[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]1=2.[ClH:29].[C:30]([N:37]1[CH:41]=[CH:40]N=[CH:38]1)(N1C=CN=C1)=O.Cl.Cl.[NH2:44][CH2:45][CH2:46][S:47][S:48][CH2:49][CH2:50][NH2:51]>CN1CCCC1=O.O1CCOCC1.C(OCC)C.C(N(C(C)C)CC)(C)C.CC(C)=O>[Cl-:29].[Cl-:29].[S:47]([CH2:46][CH2:45][NH:44][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]=1[C:2]2([CH3:1])[CH3:28])=[O:13])[S:48][CH2:49][CH2:50][NH:51][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:40]3[C:25]4[C:38](=[CH:23][CH:22]=[CH:21][CH:26]=4)[N:37]([CH3:30])[CH:41]=3)=[CH:17][C:3]=1[C:2]2([CH3:28])[CH3:1])=[O:13]

参加物

10

反応物 4

HCID 313Hydrochloric AcidHCID 5941Cystamine DihydrochlorideHCID 682631,1'-CarbonyldiimidazoleHCID 68743932HCID 68743932、化合物

生成物 1

HCID 89077752HCID 89077752、化合物

試薬・触媒・溶媒 5

HCID 180Acetone溶媒HCID 3283Diethyl Ether溶媒HCID 13387N-methyl-2-pyrrolidone溶媒HCID 312751,4-Dioxane溶媒HCID 81531Diisopropylethylamine溶媒

実験手順

10,10-dimethyl-8-(1-methyl-1H-indol-3-yl)-10H-pyrido-[1,2-a]indolium-2-carboxylate 0.37 g was solubilized in 5 mL N-methylpyrrolidinone (NMP), a solution of HCl in dry dioxane and diethyl ether (1 mL; 1N; 1:3) was added and 1,1′-carbonyldiimidazole (320 mg) was progressively added. After 3 h, 200 mg of cystamine dihyrochloride in mL diisopropylethylamine (DIPEA) were added to the mixture. After 24 h, the reaction mixture was poured in 100 mL acetone. The resulting solid was filtered, washed with acetone and dried under vacuum (340 mg, yellow powder). Analyses were in accordance with the expected structure.

後処理

  1. waitAfter 24 h
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone
  4. customdried under vacuum (340 mg, yellow powder)

出典と根拠

ORDレコード
ord-38778b693abf47bc90b7d54082ae4183
出典データセット
uspto-grants-2013_03
特許番号
US08398722B2

反応ノート

読み込み中…