Water → 6-Amino-7-bromoindan-1-ol

HRID 1947773ノート

反応式

HRID 1947773 の反応式
[NH2:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+].O>O1CCCC1>[NH2:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:12])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 534220646-Amino-7-bromo-2,3-dihydro-1H-inden-1-one

生成物 1

HCID 685011896-Amino-7-bromoindan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 6-amino-7-bromoindanone (2.4 g, 10.6 mmol) in tetrahydrofuran (150 ml) is treated with sodium borohydride (360 mg, 10.6 mmol) in portions, stirred for two hours, and treated dropwise with water. Tetrahydrofuran is evaporated and the residue is dissolved in ethyl acetate and washed with water. The separated organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-7-bromoindan-1-ol; GC/MS: 228/230 (M+1)+.

後処理

  1. customTetrahydrofuran is evaporated
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. washwashed with water
  4. dry with materialThe separated organic layer is dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-a1c06b74b55b406b8107489264cbc82f
出典データセット
uspto-grants-2013_03
特許番号
US08399490B2

反応ノート

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