N-Iodosuccinimide → 6-Fluoro-3-iodo-2-methylbenzoic acid
反応式
[I:1]N1C(=O)CCC1=O.[F:9][C:10]1[C:15]([C:16]([OH:18])=[O:17])=[C:14]([CH3:19])[CH:13]=[CH:12][CH:11]=1>FC(F)(F)S(O)(=O)=O>[F:9][C:10]1[C:15]([C:16]([OH:18])=[O:17])=[C:14]([CH3:19])[C:13]([I:1])=[CH:12][CH:11]=1参加物
4
実験手順
N-Iodosuccinimide (7.47 g, 33.2 mmol) was added dropwise to a stirred solution of 6-fluoro-2-methylbenzoic acid (5.12 g, 33.2 mmol) in trifluoromethanesulfonic acid (50 mL) at room temperature. The mixture was stirred at room temperature overnight, poured into ice/water and stirred for 3 h until solid produced. The precipitate was collected, washed with water, and air dried to give the title compound as a yellow solid.
後処理
- stirringstirred for 3 h until solid
- customproduced
- customThe precipitate was collected
- washwashed with water, and air
- customdried
出典と根拠
- ORDレコード
- ord-3d6abf5aae93473b8177b07cf1144408
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399507B2
反応ノート
読み込み中…