Methyl iodide → Tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate

HRID 1949863

反応式

HRID 1949863 の反応式
[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].[CH3:37]I.[H-].[Na+]>>[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[N:28]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])[CH3:37])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 57900446tert-Butyl tert-butyl(2-(2-chlorophenylcarbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate

生成物 1

HCID 57900249Tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate収率 78%

実験手順

Following Scheme 4, tert-butyl tert-butyl(2-(2-chlorophenylcarbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate, methyl iodide and sodium hydride were reacted to give tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate (78%). MS: (ESI+) 542.3

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-ac35cf9d0e9b4a9ea9195ea4f6142b14
出典データセット
uspto-grants-2013_03
特許番号
US08399690B2

関連ノート

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