Thionyl Chloride → 5-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride

HRID 1952847ノート

反応式

HRID 1952847 の反応式
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([OH:10])=O)[CH:4]=1.S(Cl)([Cl:13])=O>N1C=CC=CC=1>[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([Cl:13])=[O:10])[CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 218664495-(Chloromethyl)-1,2-oxazole-3-carboxylic acid

生成物 1

HCID 130018995-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride

試薬・触媒・溶媒 1

HCID 1049Pyridine触媒

実験手順

120 g (743 mmol) of 5-chloromethylisoxazole-3-carboxylic acid were refluxed together with 500 ml of thionyl chloride and 2 drops of pyridine for 10 h, then concentrated under reduced pressure and subsequently distilled under 20 torr. The product distilled at 125-133° C. to result in 78 g (58% of theory).

後処理

  1. concentrationconcentrated under reduced pressure
  2. distillationsubsequently distilled under 20 torr
  3. distillationThe product distilled at 125-133° C.
  4. customto result in 78 g (58% of theory)

出典と根拠

ORDレコード
ord-4eec5157effa424dbf14b7ea8105e34c
出典データセット
uspto-grants-2000_09
特許番号
US06114358

反応ノート

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