Dimethylformamide → 4-(4-Fluorophenoxy)benzenesulphonyl chloride

HRID 1953229ノート

反応式

HRID 1953229 の反応式
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13](O)(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Na].S(Cl)([Cl:22])=O.CN(C)C=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([Cl:22])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 5360545SodiumHCID 110225964-(4-fluorophenoxy)benzenesulfonic Acid

生成物 1

HCID 27827574-(4-Fluorophenoxy)benzenesulphonyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a slurry of 15.0 g (0.052 mol) of 4-(4-fluorophenoxy)benzenesulfonic acid□, sodium salt, in 150 mL of dry toluene was added 11.3 mL (0.155 mol, 3 equivalents) of thionyl chloride and 0.04 mL (0.5 mmol, 0.01 equivalents) of dimethylformamide. The resulting mixture was stirred at room temperature for 48 hours, filtered through diatomaceous earth, and concentrated under reduced pressure to 40 mL. This solution was used without further purification to prepare 1-[4-(4-fluorophenoxy)benzenesulfonylamino] cyclopentanecarboxylic acid benzyl ester.

後処理

  1. filtrationfiltered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure to 40 mL
  3. customThis solution was used without further purification
  4. customto prepare 1-[4-(4-fluorophenoxy)benzenesulfonylamino] cyclopentanecarboxylic acid benzyl ester

出典と根拠

ORDレコード
ord-e2518a412ec54e5b887d14cd5fbbcffd
出典データセット
uspto-grants-2000_09
特許番号
US06114568

反応ノート

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