Diisopropylethylamine → Diethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-2-aminophenylphosphonate

HRID 1953784ノート

反応式

HRID 1953784 の反応式
Br[CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[P:27](=[O:34])([O:31][CH2:32][CH3:33])[O:28][CH2:29][CH3:30].C(N(C(C)C)CC)(C)C>C(#N)C>[CH3:17][O:16][C:7]1[C:6]([O:18][CH3:19])=[N:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[P:27](=[O:34])([O:28][CH2:29][CH3:30])[O:31][CH2:32][CH3:33])[N:8]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 12482984Diethyl (2-aminophenyl)phosphonateHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

生成物 1

HCID 23297993Diethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-2-aminophenylphosphonate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

190 mg (0.579 mmol) of 5-bromomethyl-7-nitro-2,3-dimethoxyquinoxaline, 159 mg (1.2 eq.) of diethyl 2-aminophenylphosphonate and 0.2 ml (2 eq.) of diisopropylethylamine are stirred at reflux for 20 hours in 8 ml of acetonitrile. The reaction mixture is evaporated and the residue is extracted with water and ethyl acetate. The combined organic phases are dried using brine and magnesium sulfate and evaporated. The title compound is obtained as a yellow solid.

後処理

  1. customThe reaction mixture is evaporated
  2. extractionthe residue is extracted with water and ethyl acetate
  3. customThe combined organic phases are dried
  4. customevaporated

出典と根拠

ORDレコード
ord-5c1987d5ec6240529002594ae1d4839e
出典データセット
uspto-grants-2000_09
特許番号
US06117873

反応ノート

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