Peracetic Acid → HCID 14607966、化合物

HRID 1957291ノート

反応式

HRID 1957291 の反応式
[CH:1]([O:3][CH:4]=[CH2:5])=[CH2:2].[CH3:6][O:7][C:8](=[O:15])[CH2:9][C:10]1CCCC=1.C([O-])(=O)C.[Na+].C(OO)(=O)C>C(Cl)(Cl)Cl.C(O)(=O)C>[CH3:6][O:7][C:8](=[O:15])[CH2:9][CH:10]1[CH2:2][CH:1]2[O:3][CH:4]2[CH2:5]1

参加物

7

反応物 4

HCID 6585Peracetic AcidHCID 8024Vinyl etherHCID 517045Sodium AcetateHCID 12282108Methyl (cyclopent-1-en-1-yl)acetate

生成物 1

HCID 14607966HCID 14607966、化合物収率 66.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6212Chloroform溶媒

反応条件

温度
35 °C

実験手順

Preparation of a vinyl ether compound having the formula: ##STR48## A) 43.46 g (0.31 mol) of cyclopentenylacetic acid methyl ester are dissolved in 80 ml of chloroform. After the addition of 4 g of sodium acetate, 82.51 g of a 40% solution of peracetic acid in acetic acid are added dropwise thereto, with stirring, the temperature being maintained at about 35° C. The reaction mixture is then stirred for a further 5 hours at 35° C. The reaction mixture is extracted with 5% sodium hydrogen carbonate solution and then twice with water. The organic phase is then separated off and dried and residual peroxide is destroyed with sodium sulfite. After distillation of the organic phase there are obtained 32.3 g of 3,4-epoxycyclopentylacetic acid methyl ester (66.5% of theory).

後処理

  1. additionare added dropwise
  2. stirringThe reaction mixture is then stirred for a further 5 hours at 35° C
  3. extractionThe reaction mixture is extracted with 5% sodium hydrogen carbonate solution
  4. customThe organic phase is then separated off
  5. customdried
  6. customresidual peroxide is destroyed with sodium sulfite
  7. distillationAfter distillation of the organic phase there

出典と根拠

ORDレコード
ord-50b5f0dab94a4a34be7251fedd963f22
出典データセット
uspto-grants-1998_07
特許番号
US05783615

反応ノート

読み込み中…