Allyl bromide → 4-Allyloxy-2,5-dichloronitrobenzene

HRID 1957471

反応式

HRID 1957471 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([Cl:11])=[CH:4][C:3]=1[OH:12].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[CH:20]=[CH2:21]>C(#N)C>[CH2:21]([O:12][C:3]1[C:2]([Cl:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[C:5]([Cl:11])[CH:4]=1)[CH:20]=[CH2:19]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 221082,5-Dichloro-4-nitrophenol

生成物 1

HCID 190676764-Allyloxy-2,5-dichloronitrobenzene収率 93.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The product of step (a) (59.3 g, 285 mmol), 550 ml acetonitrile, 43 g (314 mmol) of potassium carbonate and 27.2 ml (314 mmol) of allyl bromide were combined and heated to reflux, and then the reaction was evaporated under reduced pressure. The mixture was extracted with diethyl ether, washed with water, and separated. The organics were dried over magnesium sulfate and stripped to yield 66.1 g of 4-allyloxy-2,5-dichloronitrobenzene product.

後処理

  1. temperatureheated
  2. temperatureto reflux
  3. customthe reaction was evaporated under reduced pressure
  4. extractionThe mixture was extracted with diethyl ether
  5. washwashed with water
  6. customseparated
  7. dry with materialThe organics were dried over magnesium sulfate

出典と根拠

ORDレコード
ord-b1d3a2b801a248e68ada93e3f0958bd5
出典データセット
uspto-grants-1998_07
特許番号
US05786301

関連ノート

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