Lithium Hydroxide → HCID 59363504、化合物

HRID 1957929ノート

反応式

HRID 1957929 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[O:9])[CH:4]=[C:3]1[C:22]([O:24]CC)=[O:23].[OH-].[Li+]>C1COCC1.O>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:20])([F:21])[F:19])=[CH:15][CH:16]=2)=[O:9])[CH:4]=[C:3]1[C:22]([OH:24])=[O:23]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 59363501HCID 59363501、化合物

生成物 1

HCID 59363504HCID 59363504、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

470 mg (1.27 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate are initially charged in 5 ml of THF, 152 mg (6.33 mmol) of lithium hydroxide in 1 ml of water are added and the mixture is stirred under reflux overnight. The reaction mixture is concentrated, the residue is acidified with 2M hydrochloric acid and the precipitate formed is filtered off with suction and dried under reduced pressure. This gives a solid.

後処理

  1. temperatureunder reflux overnight
  2. concentrationThe reaction mixture is concentrated
  3. customthe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried under reduced pressure
  6. customThis gives a solid

出典と根拠

ORDレコード
ord-ca89fc13e2a14b1f8278ccb967f19dcb
出典データセット
uspto-grants-2013_04
特許番号
US08410090B2

反応ノート

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