Methyl iodide → HCID 58405900、化合物

HRID 1957987ノート

反応式

HRID 1957987 の反応式
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1.I[CH3:17].[H-].[Na+]>CC(N(C)C)=O>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:17])[C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 592861702-chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one

生成物 1

HCID 58405900HCID 58405900、化合物収率 70%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

2-Chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one (28 g; 0.118 mol) in Dimethylacetamide (100 ml) was cooled to −5° C. and iodomethane (8.839 ml; 0.141 mmol)) was quickly added. Then, NaH (7.1 g; 0.177 mmol) was added in portions. After 1 h the reaction mixture was allowed to reach room temperature and was maintained at that temperature until complete conversion of the starting material into the desired product. The reaction mixture was diluted with water and ice and the precipitate formed was filtered and dried in vacuo. 20 g (0.083 mol; 70% yield) of a white powder were obtained.

後処理

  1. customto reach room temperature

出典と根拠

ORDレコード
ord-861c82b804234e21adb9b8d7e298b6b1
出典データセット
uspto-grants-2013_04
特許番号
US08410100B2

反応ノート

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