3-Chloroaniline → 7-(3-Chloroanilino)-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine

HRID 19593

反応式

HRID 19593 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[NH:10][N:9]=[C:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=1)[NH2:19]>C(N(C(C)C)CC)(C)C>[Cl:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=1)[NH:19][C:4]1[C:5]2[NH:10][N:9]=[C:8]([CH:11]([CH3:13])[CH3:12])[C:6]=2[N:7]=[C:2]([Cl:1])[N:3]=1

参加物

4

反応物 2

HCID 79323-ChloroanilineHCID 178440413HCID 178440413、化合物

生成物 1

HCID 1784404177-(3-Chloroanilino)-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine収率 16%

試薬・触媒・溶媒 1

HCID 81531Diisopropylethylamine溶媒

実験手順

5,7-Dichloro-3-isopropylpyrazolo[4,3-d]pyrimidine (90 mg), 1.2 mL of 3-chloroaniline and 250 μL of diisopropyl ethylamine were stirred at 60° C. for 24 hours. The reaction mixture was evaporated to dryness in vacuo. The residue was chromatographed on silica gel eluted with the following solvent system: CHCl3/heptane (100/17), to give 7-(3-chloroanilino)-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine, yield 16%, mp=257-259° C. MS (ES+): 322.3 (100%, M+H+), 324.3 (64%, M+H+). 1H NMR (CDCl3; 300 MHz): 1.54 d (6H, J=7.1 Hz); 3.60 sept (1H, J=7.1 Hz), 7.16 d (1H), 7.34 t (1H), 7.88 d (1H), 8.10 s (1H).

後処理

  1. customThe reaction mixture was evaporated to dryness in vacuo
  2. customThe residue was chromatographed on silica gel
  3. washeluted with the following solvent system

出典と根拠

ORDレコード
ord-8f8c352671c94590927e6ea4b4fc753b
出典データセット
uspto-grants-2010_06
特許番号
US07745450B2

関連ノート

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