Chlorotrimethylsilane → HCID 178505941、化合物
反応式
[Zn:1].BrCCBr.C[Si]([Cl:10])(C)C.[Cl:11][C:12]1[C:13]([F:20])=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]Cl>O1CCCC1>[Cl-:10].[Cl:11][C:12]1[C:13]([F:20])=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15][Zn+:1]参加物
6
実験手順
Under an argon atmosphere, a zinc powder (1.44 g) was suspended in tetrahydrofuran (3.6 ml), 1,2-dibromoethane (38 mg) and trimethylsilyl chloride (43 mg) were successively added at 60° C., and the mixture was stirred for 30 min. A solution of 3-chloro-2-fluorobenzyl chloride (3.58 g) in tetrahydrofuran (9 ml) was added dropwise at 60° C. to the solution prepared above. The mixture was further stirred under heating for 1 hr to give a solution of 3-chloro-2-fluorobenzylzinc chloride in tetrahydrofuran.
後処理
- customprepared above
- stirringThe mixture was further stirred
- temperatureunder heating for 1 hr
出典と根拠
- ORDレコード
- ord-92b592a78971447eba4f2353e60a94fc
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08420821B2
反応ノート
読み込み中…