Tetrahydrofuran → HCID 178459255、化合物

HRID 1968947ノート

反応式

HRID 1968947 の反応式
[CH2:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([O:13]CC)=[O:12])[CH2:7][CH2:6]1)[CH2:2][CH3:3].[OH-].[Na+].O1CCCC1>CO>[CH2:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([OH:13])=[O:12])[CH2:7][CH2:6]1)[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 178459257HCID 178459257、化合物

生成物 1

HCID 178459255HCID 178459255、化合物収率 45.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

cis/trans-Ethyl 4-(propyloxy)cyclohexanecarboxylate (D11) (39.1 g), 40% w/w sodium hydroxide solution (150 mL), tetrahydrofuran (200 mL) and methanol (150 mL) was stirred for approx. 72 hours. The solvent was partially removed then the resulting mixture was treated with ethyl acetate and water. The aqueous layer was separated, acidified with concentrated hydrochloric acid and extracted with diethyl ether. The ether layer was washed with brine, dried with anhydrous sodium sulphate and the solvent was removed to give the title compounds as oil (15.42 g).

後処理

  1. customThe solvent was partially removed
  2. additionthe resulting mixture was treated with ethyl acetate and water
  3. customThe aqueous layer was separated
  4. extractionextracted with diethyl ether
  5. washThe ether layer was washed with brine
  6. dry with materialdried with anhydrous sodium sulphate
  7. customthe solvent was removed

出典と根拠

ORDレコード
ord-262802e0c8db4176898cb42d231e0574
出典データセット
uspto-grants-2013_04
特許番号
US08426443B2

反応ノート

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