Lithium Hydroxide → (S)-2-Benzyloxycarbonylamino-4,4,4-trifluoro-butyric acid
反応式
C[O:2][C:3](=[O:21])[C@@H:4]([NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[CH2:5][C:6]([F:9])([F:8])[F:7].[Li+].[OH-]>C1COCC1.O>[CH2:14]([O:13][C:11]([NH:10][C@@H:4]([CH2:5][C:6]([F:7])([F:9])[F:8])[C:3]([OH:21])=[O:2])=[O:12])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1参加物
5
実験手順
To a solution of 250 mg (S)-2-Benzyloxycarbonylamino-4,4,4-trifluoro-butyric acid methyl ester in 2 ml THF and 0.5 ml water were added 20 mg LiOH at 0° C. The reaction mixture was brought to pH 3 by using Amberlite IR-120 ion exchange resin before being filtered and concentrated to give the crude title compound. Yield: 236 mg.
後処理
- filtrationbefore being filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-bbcce8591e6b4db996575d1d2d253c8e
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08426420B2
反応ノート
読み込み中…