Phthalic Anhydride → 2-(2-Hydroxymethylindan-2-yl)-isoindole-1,3-dione

HRID 19726

反応式

HRID 19726 の反応式
[NH2:1][C:2]1([CH2:11][OH:12])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:13]1(=O)[O:18][C:16](=[O:17])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12>O>[OH:12][CH2:11][C:2]1([N:1]2[C:16](=[O:17])[C:15]3[C:14](=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:13]2=[O:18])[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10]1

参加物

4

反応物 2

HCID 6811Phthalic AnhydrideHCID 22080542(2-Amino-2,3-dihydro-1H-inden-2-yl)methanol

生成物 1

HCID 685612062-(2-Hydroxymethylindan-2-yl)-isoindole-1,3-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
160 °C

実験手順

A mixture of (2-aminoindan-2-yl)methanol (0.407 g, 2.50 mmol) and phthalic anhydride (0.369 g, 2.50 mmol) is heated at 160° C. for 40 minutes. The reaction mixture is poured into water and extracted with chloroform. The organic phase is dried (Na2SO4) and evaporated to afford 2-(2-hydroxymethylindan-2-yl)-isoindole-1,3-dione, MH+294.

後処理

  1. extractionextracted with chloroform
  2. dry with materialThe organic phase is dried (Na2SO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-9c2a51c334da45ef9b380da3998da7ac
出典データセット
uspto-grants-2010_06
特許番号
US07745462B2

関連ノート

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