Pyridine → N-(2,6-dimethyl-3-pyridyl)-alpha-chloroacetamide

HRID 1973232

反応式

HRID 1973232 の反応式
[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.N1C=CC=CC=1.[Cl:16][CH2:17][C:18](Cl)=[O:19]>CCOCC>[CH3:1][C:2]1[C:7]([NH:8][C:18](=[O:19])[CH2:17][Cl:16])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6577Chloroacetyl chlorideHCID 769642,6-Dimethyl-3-pyridylamine

生成物 1

HCID 21493317N-(2,6-dimethyl-3-pyridyl)-alpha-chloroacetamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 2,6-dimethyl-3-aminopyridine (24.9 grams) in ether (200 ml), and pyridine (21 grams) are charged into a glass reaction vessel equipped with mechanical stirrer, thermometer and addition funnel. The reaction mixture is cooled to a temperature below about 10° C and chloroacetyl chloride (11.3 grams) is slowly added over a period of about 15 minutes. Stirring and cooling is continued for an additional period of about 1 hour to ensure the completion of the reaction. The resulting precipitate is then recovered by filtration, is washed with aqueous potassium carbonate and with water, and is dried to yield the desired product N-(2,6-dimethyl-3-pyridyl)-α-chloroacetamide.

後処理

  1. customequipped with mechanical stirrer
  2. additionthermometer and addition funnel
  3. additionis slowly added over a period of about 15 minutes
  4. temperaturecooling
  5. customthe completion of the reaction
  6. filtrationThe resulting precipitate is then recovered by filtration
  7. washis washed with aqueous potassium carbonate and with water
  8. customis dried

出典と根拠

ORDレコード
ord-da0b738a75b04e429fcb47a862999556
出典データセット
uspto-grants-1976_12
特許番号
US03996352

関連ノート

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