Tert-Butylamine → (2S)-3-[(1,1-Dimethylethyl)amino]-1,2-propanediol

HRID 1973676

反応式

HRID 1973676 の反応式
[O:1]=[CH:2][C@@H:3]([CH2:5]O)[OH:4].[C:7]([NH2:11])([CH3:10])([CH3:9])[CH3:8]>C(O)C.[Pd]>[C:7]([NH:11][CH2:5][C@H:3]([OH:4])[CH2:2][OH:1])([CH3:10])([CH3:9])[CH3:8]

参加物

5

反応物 2

HCID 6385Tert-ButylamineHCID 79014(+)-Glyceraldehyde

生成物 1

HCID 2733671(2S)-3-[(1,1-Dimethylethyl)amino]-1,2-propanediol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

30 g of (R)-glyceraldehyde, 36 cc of tert. butylamine in 800 cc of ethanol are hydrogenated over 8 g of 10 % palladium/carbon with H2 for 4 hours, the catalyst is filtered off and the solution is concentrated. (S)-1-tert.butylamino-2,3-dihydroxy-propane is obtained from ethyl acetate/ether (2:1) in the form of crystals having a M.P. of 76°-81°. [α] 20546 = -11.8° (c = 2.0; methanol).

後処理

  1. filtrationthe catalyst is filtered off
  2. concentrationthe solution is concentrated

出典と根拠

ORDレコード
ord-d34f73f2521a4902bb533a755d4efee5
出典データセット
uspto-grants-1976_12
特許番号
US03998835

関連ノート

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