Hydrochloric Acid → 2-(4-Methylphenyl)quinazolin-4(3H)-one

HRID 1973868ノート

反応式

HRID 1973868 の反応式
N1C=CC=CC=1.[OH-].[Na+].Cl.C(O)C.[CH3:13][C:14]1[CH:31]=[CH:30][C:17]([C:18]([NH:20][C:21]2[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=2[C:23]([NH2:25])=[O:24])=O)=[CH:16][CH:15]=1>>[CH3:13][C:14]1[CH:31]=[CH:30][C:17]([C:18]2[NH:25][C:23](=[O:24])[C:22]3[C:21](=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:20]=2)=[CH:16][CH:15]=1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1049PyridineHCID 14798Sodium HydroxideHCID 8196472-[(4-methylbenzoyl)amino]benzamide

生成物 1

HCID 1354521092-(4-Methylphenyl)quinazolin-4(3H)-one収率 93.1%

実験手順

A mixture of 11 ml of pyridine in 340 ml of 2 normal aqueous sodium hydroxide was heated to the reflux temperature and to the hot solution was added in one portion 16.3 g of 2-(4-methylbenzamido)benzamide. The mixture was maintained at reflux temperature for 15 minutes, then poured into 1000 ml of ice. The cold mixture was acidified with concentrated hydrochloric acid and the precipitate was cooled to give 14.1 g of white 2-(4-methylphenyl)-quinazolin-4(3H)-one, m.p. 242°-243.5° (from ethanol).

後処理

  1. temperaturewas heated to the reflux temperature and to the hot solution
  2. temperatureThe mixture was maintained
  3. temperatureat reflux temperature for 15 minutes
  4. temperaturethe precipitate was cooled

出典と根拠

ORDレコード
ord-f55a12b503544866bfe4d9cc4b9cd70a
出典データセット
uspto-grants-1976_12
特許番号
US03998951

反応ノート

読み込み中…