Sodium Hydroxide → HCID 178435591、化合物

HRID 1975663ノート

反応式

HRID 1975663 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[C:17][Si](C)(C)C)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CO.O1CCCC1.Cl>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[CH:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 178441850HCID 178441850、化合物

生成物 1

HCID 178435591HCID 178435591、化合物収率 94.2%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 0.70 g of 2-butyl-6-[(trimethylsilyl)ethynyl]-4(1H)-quinazolinone in 20 ml of methanol and 20 ml of tetrahydrofuran is added 10.0 ml of 1.0N sodium hydroxide solution. The reaction is stirred at room temperature for 2 hours and then diluted with 5% hydrochloric acid solution until the pH is 2. The resulting tan precipitate is collected filtration and dried in vacuo to yield 0.50 g of the desired product.

後処理

  1. customThe resulting tan precipitate is collected
  2. filtrationfiltration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-752de145137845ee9f0d36dc310ce2a7
出典データセット
uspto-grants-1994_02
特許番号
US05288720

反応ノート

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