Acetaminophen → 4'-Allyloxyacetanilide
反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH2:12](Br)[CH:13]=[CH2:14].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:2][C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:14][CH:13]=[CH2:12])=[CH:7][CH:6]=1)=[O:3]参加物
5
実験手順
4-Acetamidophenol (383 g, 2.53 mole), allyl bromide (338 g, 2.79 mole), and anhydrous potassium carbonate (350 g, 2.53 mole) were added to acetone (2250 ml). Under intense stirring, the heterogeneous mixture was refluxed overnight. After cooling, the inorganic salts were filtered off and the filtrate concentrated under reduced pressure. The obtained solid was used for step 2 without purification.
後処理
- temperatureUnder intense stirring, the heterogeneous mixture was refluxed overnight
- temperatureAfter cooling
- filtrationthe inorganic salts were filtered off
- concentrationthe filtrate concentrated under reduced pressure
- customThe obtained solid was used for step 2 without purification
出典と根拠
- ORDレコード
- ord-9fb489667e744678804d929c5c8c0e89
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06232430B1
反応ノート
読み込み中…