Water → HCID 178506300、化合物

HRID 19785

反応式

HRID 19785 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[Cl:10][O-].[Na+].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[Cl:10][C:7]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:4][NH:5][CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 23665760Sodium Hypochlorite

生成物 1

HCID 178506300HCID 178506300、化合物収率 77%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 3-trifluoromethyl-1H-pyrazole (500 mg, 3.67 mmol) in glacial acetic acid (5 ml) was added a 10% solution of sodium hypochlorite in water (2188 μl, 3.67 mmol). The reaction mixture was stirred at RT overnight and then neutralized with sat. sodium carbonate, and extracted with DCM. The organic layers were combined washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the desired product (480 mg, 77%) as a white solid which did not require further purification. MS (ISP) 169.0 (M−H)−.

後処理

  1. extractionextracted with DCM
  2. washThe organic layers were combined washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-64bade8d2a664b389339781759faacde
出典データセット
uspto-grants-2010_06
特許番号
US07745477B2

関連ノート

読み込み中…