Methane → HCID 20402691、化合物

HRID 1980262ノート

反応式

HRID 1980262 の反応式
Cl.[NH2:2][C:3]1[C:4]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:8])[NH:6][CH:7]=1.C.[Cl:18][CH2:19][C:20](Cl)=[O:21].[OH-].[Na+]>O>[C:9]([C:4]1[C:3]([NH:2][C:20](=[O:21])[CH2:19][Cl:18])=[CH:7][NH:6][C:5]=1[CH3:8])(=[O:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

6

反応物 4

HCID 297MethaneHCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 3042146Methanone, (4-amino-2-methyl-1H-pyrrol-3-yl)phenyl-, monohydrochloride

生成物 1

HCID 20402691HCID 20402691、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4-Amino-3-benzoyl-2-methylpyrrole hydrochloride (0.019 mole) was dissolved in water (40 ml) and the solution was treated with charcoal (0.1 g) and filtered. Toluene was added and chloroacetylchloride (0.067 mole) and aqueous NaOH (58.1 ml, 20% w/v) were added separately but simultaneously during 1 hour to the stirred two-phase solution. The reaction mixture was maintained under an inert atmosphere and at room temperature for 1.5 hour. The compound of the title which spontaneously crystallized out of the reaction mixture, was collected by filtration.

後処理

  1. filtrationfiltered
  2. additionToluene was added
  3. customThe compound of the title which spontaneously crystallized out of the reaction mixture
  4. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-501609bdceec4c06a5f8c4e9e7c1323c
出典データセット
uspto-grants-1985_04
特許番号
US04508730

反応ノート

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