Sodium hydride → HCID 20399406、化合物

反応式

[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][CH2:10][OH:11])[C:4]([CH3:7])=[CH:5][CH:6]=1.[H-].[Na+].Cl[C:15]1[CH:20]=[C:19]([C:21]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:22])[CH:18]=[CH:17][N:16]=1>COCCOC>[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][CH2:10][O:11][C:17]2[CH:18]=[C:19]([C:21]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:22])[CH:20]=[CH:15][N:16]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1

参加物

実験手順

To a suspension of 0.047 mol of 2.5-dimethyl-1-(3-hydroxypropyl)pyrrole and 0.059 mol of 80% sodium hydride in 150 ml of 1,2-dimethoxyethane, previously heated at reflux for 15 minutes and cooled, is added 0.044 mol of 2-chloro-4-piperidino carbonylpyridine, then the reaction mixture is heated two hours with reflux and evaporated to dryness. The residue is taken up with water and extracted with ethyl acetate. The organic phase is separated and evaporated to dryness. Thus, 15.4 g of an oily product are obtained.