Water → 1,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene

HRID 1982264

反応式

HRID 1982264 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([OH:9])[C:3]=1[OH:10].[H-].[Na+].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[OH2:21]>CN(C)C=O>[CH2:13]([O:9][CH:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[C:3]1([O:21][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[OH:10])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 4

HCID 962WaterHCID 7498Benzyl BromideHCID 198773,4-DichlorocatecholHCID 24758Sodium hydride

生成物 1

HCID 233177331,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In 250 ml of dimethylformamide is dissolved 8.95 g of the compound (II), and 4.80 g (2 equivalent) of 50% sodium hydride oily suspension and 10.25 g (1.3 equivalent) of benzyl bromide are added thereto. The mixture is stirred for 10 minutes under ice cooling, then poured into 200 ml of water, and sparingly soluble crystals are collected by filtration and recrystallized from hexane to give 2.096 g of 1,2-dibenzyloxy-2-hydroxy-3,4-dichlorobenzene, mp. 74°-75° C.

後処理

  1. additionare added
  2. filtrationare collected by filtration
  3. customrecrystallized from hexane

出典と根拠

ORDレコード
ord-8e725f34052144fb81d94d40b125487e
出典データセット
uspto-grants-1986_06
特許番号
US04595767

関連ノート

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