HCID 86614660、化合物 → HCID 57713313、化合物

反応式

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:29]3[CH:30]=[C:31](OC(=O)C=C)[CH:32]=[CH:33][CH:34]=3)=[C:7]([CH2:13][C:14]([NH:16][C:17]3[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][C:20]([F:27])=[CH:19][C:18]=3[OH:28])=[O:15])[C:8](=[O:12])[O:9]2)=[CH:4][C:3]=1[CH3:40]>C1COCC1.C(O)C.[OH-].[Na+]>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:29]3[CH:30]=[C:31](/[CH:6]=[CH:7]/[C:8]([OH:12])=[O:9])[CH:32]=[CH:33][CH:34]=3)=[C:7]([CH2:13][C:14]([NH:16][C:17]3[C:22]([C:23]([F:26])([F:24])[F:25])=[CH:21][C:20]([F:27])=[CH:19][C:18]=3[OH:28])=[O:15])[C:8](=[O:12])[O:9]2)=[CH:4][C:3]=1[CH3:40]

参加物

実験手順

Ethyl (2E)-3-{(3-[7-chloro-3-(2-{[4-fluoro-2-hydroxy-6-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}acrylate obtained in Reference Example 22 (0.31 g) was dissolved in a mixture of THF (5 ml) and ethanol (5 ml), and 2N aqueous sodium hydroxide solution (1.5 ml) was added thereto. After stirring for 5 hours, the reaction mixture was concentrated. To the residue was added 1N hydrochloric acid and the mixture was extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and concentrated to obtain the title compound as crystals (0.155 g, 52%).