Sodium Hydroxide → 1-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

HRID 1985630ノート

反応式

HRID 1985630 の反応式
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([I:17])[CH:13]=2)[N:8]([CH2:18][CH3:19])[CH:7]=1)=[O:5])C.[OH-].[Na+]>C1COCC1.O>[CH2:18]([N:8]1[C:9]2[C:14](=[CH:13][C:12]([I:17])=[CH:11][CH:10]=2)[C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7]1)[CH3:19]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 57720090Ethyl 1-ethyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate

生成物 1

HCID 179804871-Ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid収率 106.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

1,4-Dihydro-1-ethyl-6-iodo-4-oxo-quinoline-3-carboxylic acid ethyl ester (7.5 g, 0.02 mol) was suspended in THF (75 mL), NaOH (2 equiv.) solution in water (75 mL) was added and the mixture was stirred at 80° C. for 24 hours. After THF was evaporated, the solution was acidified to pH 5 using HCl. The obtained precipitate was filtrated off and dried under reduced pressure yielding the title compound (7.3 g).

後処理

  1. customAfter THF was evaporated
  2. filtrationThe obtained precipitate was filtrated off
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-9cd744ffd07e4e70842c3402eec267e1
出典データセット
uspto-grants-2009_06
特許番号
US07547679B2

反応ノート

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