Toluene → 7-bromo-4-(bromoacetyl)-2H-chromen-2-one

HRID 1988212

反応式

HRID 1988212 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]([O:15]CC)=[CH2:14])=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[Br:18]N1C(=O)CCC1=O.C1(C)C=CC=CC=1>C1COCC1.O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13](=[O:14])[CH2:15][Br:18])=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 1140TolueneHCID 67184N-bromobutanimideHCID 233702047-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one

生成物 1

HCID 233702397-bromo-4-(bromoacetyl)-2H-chromen-2-one

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 7-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one (2.0 g, 6.8 mmol) in THF and H2O is added N-bromosuccinimide (1.3 g, 14.2 mmol) with stirring for 30 min. Toluene is added and the solvent is evaporated. The residue is chromatographed on silica gel (hexane/EtOAc; 80:20) to give the title compound.

後処理

  1. customthe solvent is evaporated
  2. customThe residue is chromatographed on silica gel (hexane/EtOAc; 80:20)

出典と根拠

ORDレコード
ord-1b8169eddea0484994e466ac59ade112
出典データセット
uspto-grants-2009_06
特許番号
US07553973B2

関連ノート

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