1,1'-Carbonyldiimidazole → 6-bromo-1,2-benzisoxazol-3-ol
反応式
C(N1C=CN=C1)(N1C=CN=C1)=O.[Br:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([NH:20]O)=[O:19])=[C:16]([OH:24])[CH:15]=1>O1CCCC1>[Br:13][C:14]1[CH:23]=[CH:22][C:17]2[C:18](=[O:19])[NH:20][O:24][C:16]=2[CH:15]=1参加物
4
実験手順
A solution of carbonyldiimidazole (0.75 g) in dry tetrahydrofuran (15 ml) was added to a refluxing solution of 4-bromo-N,2-dihydroxybenzamide (Intermediate 23) (0.56 g) in dry tetrahydrofuran (10 ml) then stirred for 2 h. The solvent was removed under vacuum, the residue was suspended in water and 2N hydrochloric acid (10 ml) was added. The resulting precipitate was collected by filtration, washed with water then cyclohexane and dried to give the title compound as a cream solid (0.37 g).
後処理
- customThe solvent was removed under vacuum
- addition2N hydrochloric acid (10 ml) was added
- filtrationThe resulting precipitate was collected by filtration
- washwashed with water
- dry with materialcyclohexane and dried
出典と根拠
- ORDレコード
- ord-1975a99a796442f0bc7b5298016be985
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07642276B2
反応ノート
読み込み中…