HCID 68971803、化合物 → HCID 69084677、化合物
反応式
[CH3:1][C:2]1[N:7]2[N:8]=[N:9][N:10]=[C:6]2[C:5]([N+:11]([O-])=O)=[C:4]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])[C:3]=1[CH3:19]>[Pd].C(#N)C>[NH2:11][C:5]1[C:6]2[N:7]([N:8]=[N:9][N:10]=2)[C:2]([CH3:1])=[C:3]([CH3:19])[C:4]=1[NH:14][CH2:15][CH2:16][CH2:17][OH:18]参加物
4
実験手順
A mixture of 3-[(5,6-dimethyl-8-nitrotetraazolo[1,5-α]pyridin-7-yl)amino]propan-1-ol (4.00 g, 15.0 mmol) and 10% palladium on carbon (0.40 g) in acetonitrile (75 mL) was hydrogenated at 50 psi (3.5×105 Pa) on a Parr apparatus for 16 hours. The mixture was filtered through CELITE filter agent, which was rinsed with methanol. The filtrate was concentrated under reduced pressure to yield 3.48 g of 3-[(8-amino-5,6-dimethyltetraazolo[1,5-α]pyridin-7-yl)amino]propan-1-ol.
後処理
- filtrationThe mixture was filtered through CELITE
- filtrationfilter agent, which
- washwas rinsed with methanol
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-881f04af0a6c4b82951848056586ada7
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07648997B2
反応ノート
読み込み中…