Methanol → 4-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-one
反応式
[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:11][CH2:10]2)=[N:5][N:4]=[C:3]1[SH:13].[CH3:14]O.CI>[OH-].[Na+]>[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:10][CH2:11]2)=[N:5][N:4]=[C:3]1[S:13][CH3:14]参加物
5
実験手順
198 g of compound obtained according to (b) is dissolved in 500 ml of 2 N NaOH, and 500 ml of methanol and 150 g of methyl iodide are added. The reaction mixture is stirred at 20° to 30° C. for 6 hours. The crystals which have formed are filtered off with suction, washed and dried to yield 174.5 g of final product (dried in vacuo at 40° C.); white crystals; melting point 115° to 116° C.; yield 82.3% of theory.
後処理
- customThe crystals which have formed
- filtrationare filtered off with suction
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-43aaa1ef63c745ed8c05b41eef92b18e
- 出典データセット
- uspto-grants-1983_09
- 特許番号
- US04402733
反応ノート
読み込み中…