Pyridine → 2-Hydrazinyl-5-phenylpyrazine

HRID 1995061

反応式

HRID 1995061 の反応式
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1.N1C=CC=CC=1.O.[NH2:21][NH2:22]>O>[NH:21]([C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:22]

参加物

5

反応物 3

HCID 1049PyridineHCID 24654Hydrazine hydrate (1:1)HCID 12366642-Chloro-5-phenylpyrazine

生成物 1

HCID 131998672-Hydrazinyl-5-phenylpyrazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1.0 g. of 2-chloro-5-phenylpyrazine, m.p. 98°-99° C., 5.0 ml. of pyridine and 5.0 ml. of hydrazine hydrate is heated at reflux for 1.5 hours. The solution is cooled, and 20 ml. of water is added. The colorless crystalline product is collected and air dried. The crude product is recrystallized from aqueous ethanol to yield 0.35 g. of the product of the example as colorless needles, m.p. 128°-130° C.

後処理

  1. additionA mixture of 1.0 g
  2. temperatureat reflux for 1.5 hours
  3. temperatureThe solution is cooled
  4. customThe colorless crystalline product is collected
  5. customair dried
  6. customThe crude product is recrystallized from aqueous ethanol
  7. customto yield 0.35 g

出典と根拠

ORDレコード
ord-21ffbdf0805c4b64b5feca5098d9f0ce
出典データセット
uspto-grants-1983_09
特許番号
US04402958

関連ノート

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