Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

HRID 1995256ノート

反応式

HRID 1995256 の反応式
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1.CN(C)C=O.S(Cl)([Cl:22])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10]([Cl:22])=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 129061732-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

生成物 1

HCID 129061742-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide were heated with stirring at 55°, and an addition was then made dropwise in the course of 1 hour of a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform. The reaction mixture was subsequently refluxed for 16 hours and afterwards concentrated in vacuo. The resulting product was used directly for further reactions.

後処理

  1. additionan addition
  2. temperatureThe reaction mixture was subsequently refluxed for 16 hours
  3. concentrationafterwards concentrated in vacuo

出典と根拠

ORDレコード
ord-0d83799187bd46c1866ebecc757701c5
出典データセット
uspto-grants-1983_09
特許番号
US04404020

反応ノート

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