Sodium borohydride → 4-(2,2,2-Trifluoroethyl)phenol
反応式
Cl[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[C:3]([F:6])([F:5])[F:4].[BH4-].[Na+]>C1COCC1>[F:4][C:3]([F:5])([F:6])[CH2:2][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1参加物
4
実験手順
To a solution of 4-(1-chloro-2,2,2-trifluoroethyl)phenol (3.60 g, 17.1 mmol) in THF was added sodium borohydride (0.903 ml, 25.6 mmol) in one portion. The reaction was stirred at RT for 18 h, and then quenched with MeOH. The resulting mixture was concentrated and diluted with EtOAc. After washed with water and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was dried in vacuum to afford 4-(2,2,2-trifluoroethyl)phenol as a colorless oil. MS m/z: 175(M−1).
後処理
- customquenched with MeOH
- concentrationThe resulting mixture was concentrated
- additiondiluted with EtOAc
- washAfter washed with water and brine
- dry with materialThe organic layer was dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customThe residue was dried in vacuum
出典と根拠
- ORDレコード
- ord-003fc360faab496482ebd362427b4fc9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745484B2
反応ノート
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