Methyl iodide → 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide
反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2].[CH3:10][I:11]>CC(C)=O>[I-:11].[CH2:1]([N+:3]1([CH3:10])[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2]参加物
4
実験手順
To a solution of 1-ethyl-4-oxopiperidine (25 g, 0.197 mol) in acetone (250 ml) at RT in a water bath was added methyl iodide (15.5 ml, 0.25 mol) at such a rate to keep the temperature below 30° C. The mixture was filtered and the precipitate washed with acetone and dried to yield 1-ethyl-1-methyl-4-oxopiperidinium iodide (45 g) (LC/MS: Rt 0.38, [M+H]+ 143).
後処理
- customthe temperature below 30° C
- filtrationThe mixture was filtered
- washthe precipitate washed with acetone
- customdried
出典と根拠
- ORDレコード
- ord-ae618f52af61445c9898a909d30788df
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745638B2
反応ノート
読み込み中…