1-Bromopropane → 3-Cyclopropyl-7-propylxanthine

HRID 2032

反応式

HRID 2032 の反応式
[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][NH:9][C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]1.[H-].[Na+].[H][H].Br[CH2:20][CH2:21][CH3:22]>CN(C)C=O>[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][N:9]([CH2:20][CH2:21][CH3:22])[C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]1

参加物

6

反応物 4

HCID 78401-BromopropaneHCID 24758Sodium hydrideHCID 30589961H-Purine-2,6-dione, 3,7-dihydro-3-cyclopropyl-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 196892703-Cyclopropyl-7-propylxanthine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

9.6 g (0.05 mol) of 3-cyclopropylxanthine were suspended in 150 ml of dimethylformamide and slowly deprotonated using 1.45 g (0.06 mol) of sodium hydride. When evolution of hydrogen was at an end, the solution was heated to 60° C. and treated dropwise with 6.77 g (0.055 mol) of bromopropane. After stirring at 70° C. for 3 hours, the solution was filtered, the dimethylformamide was evaporated under reduced pressure and the residue was crystallized from diisopropyl ether.

後処理

  1. filtrationthe solution was filtered
  2. customthe dimethylformamide was evaporated under reduced pressure
  3. customthe residue was crystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-8e167d88150f459d95e6145c9ec1c182
出典データセット
uspto-grants-1998_03
特許番号
US05728686

関連ノート

読み込み中…