[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][NH:9][C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]1.[H-].[Na+].[H][H].Br[CH2:20][CH2:21][CH3:22]>CN(C)C=O>[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][N:9]([CH2:20][CH2:21][CH3:22])[C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]19.6 g (0.05 mol) of 3-cyclopropylxanthine were suspended in 150 ml of dimethylformamide and slowly deprotonated using 1.45 g (0.06 mol) of sodium hydride. When evolution of hydrogen was at an end, the solution was heated to 60° C. and treated dropwise with 6.77 g (0.055 mol) of bromopropane. After stirring at 70° C. for 3 hours, the solution was filtered, the dimethylformamide was evaporated under reduced pressure and the residue was crystallized from diisopropyl ether.
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