Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol
反応式
[N+:1]([CH3:4])([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH:15]=[O:16]>O1CCCC1>[F:11][C:12]1[CH:13]=[C:14]([CH:15]([OH:16])[CH2:4][N+:1]([O-:3])=[O:2])[CH:17]=[C:18]([F:20])[CH:19]=1参加物
5
実験手順
Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.
後処理
- filtrationfilter
- washwash with ethyl acetate
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-2cf9865e0403426b8bcade080e174cea
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745438B2
反応ノート
読み込み中…