Ethanolamine → 2-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol

HRID 2036314ノート

反応式

HRID 2036314 の反応式
Br[CH2:2][CH2:3][N:4]1[C:12]([O:13][CH3:14])=[N:11][C:10]2[C:5]1=[N:6][C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:8][C:9]=2[NH2:15].[NH2:21][CH2:22][CH2:23][OH:24]>C(#N)C>[NH2:15][C:9]1[N:8]=[C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:6]=[C:5]2[C:10]=1[N:11]=[C:12]([O:13][CH3:14])[N:4]2[CH2:3][CH2:2][NH:21][CH2:22][CH2:23][OH:24]

参加物

4

反応物 2

HCID 700EthanolamineHCID 589428939-(2-Bromoethyl)-2-butoxy-8-methoxy-9H-purin-6-amine

生成物 1

HCID 585519292-{[2-(6-Amino-2-butoxy-8-methoxy-9H-purin-yl)ethyl]amino}ethanol

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
70 °C

実験手順

To the compound obtained by Example 2-39 step (i) (300 mg) in acetonitrile (5 ml) was added 2-aminoethanol (265 mg) and heated at 70° C. for 24 hours. The reaction mixture was purified by column chromatography (ethyl acetate:7N ammonia-methanol 95:5) to give the titled compound. Yield: 295 mg (100%).

後処理

  1. customThe reaction mixture was purified by column chromatography (ethyl acetate:7N ammonia-methanol 95:5)

出典と根拠

ORDレコード
ord-0493e16e68d74f308e7661a22467c15b
出典データセット
uspto-grants-2013_11
特許番号
US08575180B2

反応ノート

読み込み中…