Acetonitrile → 7-(Benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine

HRID 2036951ノート

反応式

HRID 2036951 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[CH2:12]([SH:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C.C(#N)C>O>[CH2:12]([S:19][C:6]1[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=[C:2]([Cl:1])[CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 7509Benzyl mercaptanHCID 8471TriethylamineHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

生成物 1

HCID 583137227-(Benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine収率 96%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To the reaction flask, 5,7-dichloropyrazolo[1,5-a]pyrimidine (4.1 g, 22 mmol) was added along with benzyl mercaptan (2.8 mL, 22 mmol), triethylamine (3.1 mL, 22 mmol), and acetonitrile (71 mL). The reaction was stirred at room temperature for 3 hours then diluted with water, filtered and washed with water. The product, 7-(benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine, was collected as a solid in 96% yield after drying under vacuum overnight. LCMS (M+1=276)

後処理

  1. filtrationfiltered
  2. washwashed with water
  3. customThe product, 7-(benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine, was collected as a solid in 96% yield
  4. customafter drying under vacuum overnight

出典と根拠

ORDレコード
ord-b9763dc2d3994f86895725a98e478363
出典データセット
uspto-grants-2013_11
特許番号
US08575177B2

反応ノート

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