Lithium Hydroxide → trans-2-(Methylpropylcarbamoyl)-cyclo-propane carboxylic acid
反応式
[OH-].[Li+].C([O:5][C:6]([C@@H:8]1[CH2:10][C@H:9]1[C:11](=[O:17])[N:12]([CH3:16])[CH2:13][CH2:14][CH3:15])=[O:7])C>O1CCCC1>[CH3:16][N:12]([CH2:13][CH2:14][CH3:15])[C:11]([C@@H:9]1[CH2:10][C@H:8]1[C:6]([OH:7])=[O:5])=[O:17]参加物
4
実験手順
Add 1 N lithium hydroxide (25.6 mL, 25.59 mmol) to a solution of trans-2-(methylpropylcarbamoyl)-cyclopropane carboxylic acid ethyl ester (1.02 g, 5.1194 mmol) in tetrahydrofuran (30 mL). Stir vigorously for 2 days at room temperature. Concentrate and treat with water (50 mL) and extract with diethyl ether (50 mL). Acidify the aqueous layer with 1 N hydrochloric acid (26 mL) and extract with diethyl ether (3×125 mL). Combine the organic extracts, dry (magnesium sulfate) and concentrate to give the title compound as a racemic mixture (0.84 g, 89%).
後処理
- concentrationConcentrate
- additiontreat with water (50 mL)
- extractionextract with diethyl ether (50 mL)
- extractionextract with diethyl ether (3×125 mL)
- dry with materialCombine the organic extracts, dry (magnesium sulfate)
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-ad32ed6536cb4c1caa629890dcc73e16
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745438B2
反応ノート
読み込み中…