N-bromobutanimide → Ethyl 3-(4-bromo-3-hydroxyphenyl)propanoate
反応式
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([OH:13])[CH:8]=1)[CH3:2].[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:15])=[C:9]([OH:13])[CH:8]=1)[CH3:2]参加物
4
実験手順
To a −10° C. solution of 3-(3-hydroxy-phenyl)-propionic acid ethyl ester (2.0 g, 10.31 mmol) in chloroform (0.2 M, 51 mL) was added N-bromosuccinimide (1.93 g, 10.83 mmol). After stirring at RT overnight, the solution was concentrated in vacuo and purified by flash column chromatography (SiO2, 5% to 15% ethyl acetate/hexanes) to give the product as a colorless oil (0.45 g, 16%).
後処理
- concentrationthe solution was concentrated in vacuo
- custompurified by flash column chromatography (SiO2, 5% to 15% ethyl acetate/hexanes)
出典と根拠
- ORDレコード
- ord-f0d5ac09597b4d6ca5b9c78acbcbeecc
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586631B2
反応ノート
読み込み中…