Sodium Hydroxide → HCID 67464828、化合物
反応式
[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]([CH2:10][C:11]([O:13]CC)=[O:12])[N:4]=1)[CH3:2].[OH-].[Na+]>O1CCCC1.O>[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]([CH2:10][C:11]([OH:13])=[O:12])[N:4]=1)[CH3:2]参加物
5
実験手順
Ethyl 3,5-diethyl-1H-pyrazole-1-acetate (2.79 g, 13.3 mmol) (i.e. the product of Example 15, Step B) in tetrahydrofuran (10 mL) was treated with sodium hydroxide (1.0 g) in water (7.5 mL) The reaction mixture was then stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and washed with diethyl ether. The resulting aqueous layer was acidified with concentrated hydrochloric acid to give a white precipitate. The precipitate was filtered and dried in air to give 690 mg of the title compound.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- washwashed with diethyl ether
- customto give a white precipitate
- filtrationThe precipitate was filtered
- customdried in air
出典と根拠
- ORDレコード
- ord-bfa68867fba0460c8472e74c1bf36b72
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08586611B2
反応ノート
読み込み中…