Isopropylamine → HCID 67440464、化合物

HRID 2045643ノート

反応式

HRID 2045643 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([C:11]2[C:20]([CH3:22])([CH3:21])[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:23]([O:25][CH3:26])=[O:24])[CH:17]=3)[N:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH3:27][CH:28]([NH2:30])[CH3:29].C(N(CC)C(C)C)(C)C>ClCCl>[CH:28]([NH:30][S:2]([C:5]1[CH:6]=[C:7]([C:11]2[C:20]([CH3:22])([CH3:21])[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:23]([O:25][CH3:26])=[O:24])[CH:17]=3)[N:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3])([CH3:29])[CH3:27]

参加物

5

反応物 3

HCID 6363IsopropylamineHCID 81531DiisopropylethylamineHCID 86658613HCID 86658613、化合物

生成物 1

HCID 67440464HCID 67440464、化合物収率 59.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of methyl 2-(3-(chlorosulfonyl)phenyl)-3,3-dimethyl-3,4-dihydroquinoline-6-carboxylate (393 mg, 1.0 mmol) in dichloromethane (4 mL) was added propan-2-amine (60 mg, 1.0 mmol) and N,N-diisopropylethylamine (258 mg, 2.0 mmol). The resultant mixture was stirred overnight. The mixture was purified on preparative Thin layer chromatography to afford 245 mg of methyl 2-(3-(N-isopropylsulfamoyl)phenyl)-3,3-dimethyl-3,4-dihydroquinoline-6-carboxylate, which was used directly.

後処理

  1. customThe mixture was purified on preparative Thin layer chromatography

出典と根拠

ORDレコード
ord-52c2461d88d0424c8e23198bf1fe66e0
出典データセット
uspto-grants-2013_11
特許番号
US08586747B2

反応ノート

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