Water → 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

HRID 2046451ノート

反応式

HRID 2046451 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[C:11](=[CH:15]N(C)C)[C:10](=[O:19])[CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:21][C:22]([NH2:24])=[NH:23].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[NH2:23][C:22]1[N:24]=[CH:15][C:11]2[C:10](=[O:19])[CH2:9][CH:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:13][C:12]=2[N:21]=1

参加物

6

反応物 4

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 10340Sodium CarbonateHCID 5670705-(4-Chlorophenyl)-2-[(dimethylamino)methylene]-1,3-cyclohexanedione

生成物 1

HCID 27723712-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5-(4-Chloro-phenyl)-2-dimethylaminomethylene-cyclohexane-1,3-dione (0.8 g, 2.89 mmol) from stage 1, guanidine hydrochloride (551 mg, 5.77 mmol) and sodium carbonate (919 mg, 8.67 mmol) were stirred in ethanol (10 ml) at reflux for 4 h. The reaction mixture was cooled to ambient temperature and water (10 ml) was added to the flask. The resulting precipitate was recovered by filtration, washed with water (15 ml), heptane (15 ml) and air dried.

後処理

  1. temperatureat reflux for 4 h
  2. filtrationThe resulting precipitate was recovered by filtration
  3. washwashed with water (15 ml), heptane (15 ml) and air
  4. customdried

出典と根拠

ORDレコード
ord-e209105160994304acc27b198ef271aa
出典データセット
uspto-grants-2013_11
特許番号
US08592430B2

反応ノート

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